The curious case of ice hats

A key indicator that someone is going to grow up to be a scientist, I think, is a propensity to look at the world and ask “What the…?!?”.

Having a live-in physicist has proven extremely useful for satisfying my (often fleeting) curiosity about lots of things, e.g., what is electricity? Why can’t something go faster than the speed of light? Or — stealing something from Katey’s curiosity — what would happen if there was no moon?

I was therefore surprised when my physicist couldn’t explain my recent curiosity, stemming from a bizarre finding in my freezer (Figure 1).

Figure 1. A picture of my actual ice cube tray and most recent batch of ice cubes. About 83% of the ice cubes in this batch were as expected (hat-less). The remainder had these astonishing little hats.

What the heck was this hat doing on my ice cube?!? I thought this wonder of science was sufficiently interesting to bring it up at lunch with my labmates. They offered a bunch of hypotheses for what could cause an ice hat. Maybe something was vibrating underneath the ice cube tray, or something was dripping from above it. Megan had the most inspired idea: could the formation of the ice hat have something to do with the purity of the water? The water in State College is notoriously hard, containing a lot of calcium. She thought that if I hadn’t filtered my water before freezing it, these impurities could provide a substrate around which the ice crystals could form. Turns out Megan was right, only in reverse.

Water with impurities does form ice around those impurities, but it also forms ice relatively slowly. Without impurities, water freezes so quickly that the water beneath the surface begins to freeze before the surface (which starts freezing first) is frozen solid. Since water expands as it freezes, the developing ice below pushes water up through the part of the surface that isn’t yet frozen. The surface of this emerging water freezes quickly too, so that as the water is pushed up and through a hole in the surface it freezes into a tube, which funnels more water upwards. This process generates what is known as an ice spike (though, I prefer the friendlier ‘ice hat’). The faster the water freezes, the taller the spike. With impurities, the water freezes slowly enough that the surface is frozen shut before a spike is made.

Apparently physicists could have answered my question, I just asked the wrong one. Two physicists published a paper in the Journal of Glaciology on this exact topic. Academia may be the only place where people get paid to satisfy their “what the…?!?” curiosities and that is pretty awesome.

Ice spikes are also pretty awesome. Make ice cubes from filtered water; impress your friends!

The end of the affair

To do science professionally requires a decade or so of training. Most of the training is a series of apprenticeships, where practicing scientists like me attempt to provide something which will empower the PhD students and post-docs to become more like, well, me. Quite what we provide is a total mystery. Relevant verbs: cajole, encourage, shape, unleash, stand back, teach, learn, watch, stimulate, underpin, raise, console, cheer, challenge, expand, argue, backup, disagree….

The process generates a type of personal relationship unlike any I have experienced elsewhere in my life. (Nicole calls me boss, and we both love the irony.) You spend significant chunks of your life – and especially theirs – together. You live with them through the highs and the lows, the cock-ups and the dead ends, the good ideas and the blowouts, the rejections and the eventual acceptances. Particularly when you are starting a research group, your future is totally, totally entangled in their future. And you struggle, almost daily, to provide the right balance of stretch and support (mmm, sounds like an underwear commercial). For me at least, it is hard not to get emotionally invested in the apprentices – it’s hard not to really care, especially as you watch them grow. Many early-career advisers struggle to get the personal/professional balance right.

But then the apprentices fledge. For a year or two, the relationship stutters along, usually as the last papers are wrapped up, or they come to you for career advice and endless reference letters. Then the whole thing more or less stops. You mostly hear from them only when they want something (usually another reference letter). You see them at meetings occasionally, when it is always good to have a beer and talk about the old times and find out how their lives are going. For those who have become advisers themselves, it is particularly good to hear how they are doing with their own apprentices. But for the most part, your ex-apprentices are gone from your life.

That is exactly how it was with me and my adviser. He opened the world for me, gave me extraordinary opportunities and insisted (screamed, shrieked, demanded) that I take them. Never once did he accept poor performance (“what do you call this?”). He gave me as much time with him as I could take. He surrounded me with the smartest people in evolutionary biology and leaders in the then nascent field of infectious disease ecology and he insisted I talk with them, work with them, learn from them. And by totally outrageous example, he taught me that you could live life to the full in this business. Then, after 7 years in his orbit, I just left, only getting in contact when I needed a reference letter.

I always felt bad about that. But somehow, now that I am more or less the age he was when I fledged, and after 30 or so of my own apprentices have flown the nest, it feels like that is the way it should be.

Bon voyage, Silvie and Kirjn.

Leaving the nest…

October 2004 – As a young 22 year old, I stepped into the office of Andrew in Edinburgh, Scotland. That was the start of a long and fantastic journey together. I was about to start a six-month Masters research project in his lab. Soon, my eyes were opened to the fantastic research environment of the University of Edinburgh, the quality and the enthusiasm of everybody in the lab, both PhD students and postdocs, and the stimulating research questions Andrew posed. After the 6 months were over, Andrew asked me to apply for a scholarship to do a PhD in his lab after I would finish my Masters. Two years later I would start my PhD.

November 2012 – Now 30 years old, I am once again in Andrews office, this time at Penn State and we say our goodbyes. With a lump in my throat I walk back to my office to clean up my desk. The past eight years have been really good and it is sad and frankly quite scary to leave it all behind. Much has changed, not only did I obtain my Masters and PhD, I also moved to Penn State and ‘obtained’ a husband and two children. Times change. It is time to leave my scientific dad and stand on my own feet.

Leaving Andrew is scary. How do you know you can do all this on your own? I guess time will tell. Andrew has been one of the best mentors one can wish for and has always worked hard to prepare us for this moment. He has always made me feel that he deeply cares, which I want to thank him for, a lot. The Read group and Thomas lab, past and present are a fantastic group of enthusiastic, smart and fun people. I will miss each and everyone of them, and especially my dear office mates Laura and Jessi; my tea water providers (and listening ears) Vicki and Nicole; Katey and her crazy and funny rants, all my lunch buddies and, most importantly, Megans baking. I’m sure we’ll see each other (including baked goods) again!

All, keep up the great work, can’t wait to see all the new papers coming out. Enjoy and benefit your time in this group, it will end before you know it.

Andrew, I will miss you! Thank you for all you’ve done.  Luckily leaving the nest doesn’t mean being out of touch.

Narwhals

A few weeks ago at the pub, Nicole mentioned that it can be hard gauge when a fellow postdoc (anonymous for this blog post) is being funny on purpose. “Yeah” I said, “I remember s/he said something about narwhals being mythical and I’m still not sure if s/he was joking or not.” And thus began the great narwhal debate of 2012.

As it turns out, Nicole didn’t learn about narwhals until college. An advanced age for what I consider to be basic knowledge, acquired prior to the limits of my memory. This revelation led to wild speculation as to the reason for disparities in narwhal knowledge. Based on the geography of our childhoods, Nicole hypothesized that distance to the ocean is associated with early knowledge of narwhals. Alternatively, I hypothesized that knowledge of narwhals is associated with an affinity for experimental biology, in contrast to modeling.

Since we are scientists, I decided we should confront our hypotheses with data, or at least with a non-random sampling of people on Facebook. Luckily, it turns out that people are always interested in talking about narwhals (something to keep in mind next time you’re in a social situation that requires small talk).

Here is a Google map showing the geographic distribution of responses.

As you can see, responses were heavily skewed towards the U.S. This brings up the first issue with the data: U.S. respondents tended to provide their location to state while European respondents largely responded by country. After consulting with Silvie, I’ve decided to leave the data as is (state level for U.S., country level for non-U.S.) given the size of European countries versus the U.S.

First, testing Nicole’s hypothesis: is there a relationship between narwhal knowledge and geography?

Age of first narwhal knowledge by distance to ocean (estimated very scientifically with the scale bar in Google maps).

Second, testing my hypothesis: is there a relationship between narwhal knowledge and career path?

Age first narwhal knowledge by career class.

As you can see, the data does not support either of our hypotheses. This has lead to follow up conversations, discussing research methodologies and generating alternative hypotheses (e.g. does parental career matter more than your own career?) Again, narwhals are a great conversation starter.

I also polled people on what the letter N stands for. This was mostly an excuse to try making a word cloud in R, but also one of the reasons that I think children learn about narwhals early is because they are often used to illustrate alphabets. Obviously responses were a tiny bit biased by the preceding questionnaire about narwhals but surprisingly, not everyone said narwhals.

Word cloud of what the letter N stands for in an illustrated alphabet.

1L of urine yields 6h of electricity

Though they'd be too young to drive a car in the US, I'm pretty sure these girls could take one apart and put it back together

For the third year in a row, innovators and inventors in Africa have been gathered together by the international organization Maker Faire Africa to share their ideas on how to solve pressing problems in their developing countries. This year, Duro-Aina Adebola, Akindele Abiola, Faleke Oluwatogyin, and Bello Eniola (14, 14, 14, and 15 years old) developed a device that converts something we don’t need into something we do- urine to electricity! (I think they should call it a “Power Pot.” Get it? Instead of flower pot? I bet MBT thought it was funny.)

Essentially, it filters and purifies hydrogen gas from the breakdown of urea and uses that to fuel a generator, to make the electricity. I learned all of this from an article that someone posted on facebook from The Next Web, but then found an article from Wired that was kind of a downer about it. The girls’ design might not be capable of generating a net gain in electricity…which is a bummer. Anyway, I just wanted to post this because I had never heard of Maker Faire Africa and wanted to spread the word about what seems like a great organization (in spite of their somewhat uninformative website). And also because I am awestruck by the young and ambitious (and mechanically-gifted).

I think my best idea when I was a kid- about 10, maybe?- could have been giving sick people healthy germs to make them better, but I never actually got around to testing it. Even though I felt like perhaps it actually was a good idea when I heard about fecal transplants (and, you know, all of the within-host competition work in the lab), I think I had been planning something along the lines of giving people spoonfuls of my spit, so I’m not sure that I really missed an opportunity to save lives there.

The Big Gulp

It’s a catchy phrase.

Despite the fascination of basic biology (e.g., the gorgeous mosquito below), we scientists often fail to explain what we mean without resorting to jargon. So it’s refreshing when researchers coin descriptive names rather than mysterious acronyms. It’s certainly not easy to avoid jargon when describing the life cycle of a complicated organism like malaria, which is essentially a parasitic algae that invades red blood cells and eats them up from the inside. Today I read about the “big gulp“, which is the technical term (really) for the process by which a thirsty malaria parasite takes a big drink of red blood cell. The parasite flattens like a pancake and the edges curve inward to seal around a large chunk of hemoglobin and goo (to use another technical term)–a big gulp that has been captured on film. If another group of researchers had been the first to describe this behavior, they might have named it “intracellular pinocytosis“, which would have been tragic. Nothing fails to convey enthusiasm for basic biology like dry terminology.

The Magic of Mosquitoes

With all this discussion of weebles, success,and impact (or the lack of it!) I can’t help, but wonder about why I’m in this business anyway.  I certainly want to help people, but there is often a long and winding road from the basic research I conduct to stopping cases of malaria or dengue. The reality is that my work might not help anyone, anywhere, ever.

I have one simple goal and that is to convince the vector biology community we should study mosquitoes as we would any other animal. Just because some mosquitoes transmit pathogens that happen to infect humans does not mean they forfeit the right to be complicated or are excused from evolution outside of interactions with us or the parasites we care about.

These animals lead fantastically beautiful and complex lives outside of transmitting diseases. I believe that by lifting the blinders and looking at these insects outside of their role as vectors, that we will find new ways to control disease. We will also have the privilege of witnessing new and amazing things; moments that make nature seem like magic.

The incredibly beautiful Sabethes cyaneus. Males of this species perform dances for their ladies to convince them to mate. Stolen from (http://www.flickriver.com/photos/tags/lalat/interesting/)

I’m thoroughly enjoying working on the interaction between malaria parasites and mosquitoes, but sometimes I pine for the days when my mosquito had no pathogens and I was simply asking, “What are you doing? And why?”.

I feel like I’ve been distracted from my simple goal.  Hopefully, someday I will get back to basics. NIH probably wouldn’t fund it, but it is the magic that drew me to science and it is the magic that will allow me to endure.

Weeble wobbles

Today marks the two month anniversary of my arrival in State College and the beginning of my postdoc in Matt and Andrew’s group. Not surprisingly, I’ve spent a lot of the past two months thinking about career transitions.

One thing I’ve come to realize is that moving to a new lab is a bit like being a Weeble. If you’re not familiar, a Weeble is an egg shaped toy with a weight in the bottom. When you push a Weeble, it swings around wildly until the heavy bottom brings it back to a stable and upright position. Likewise, when you transition between labs, some wobbling is to be expected but hopefully you too will eventually stabilize, thanks to your heavy bottom (or solid foundation, if you prefer).

Obviously career transitions are not unique to science, as most people switch jobs at some point in their lives. But in science, such changes are notably frequent and largely regarded as necessary. For example, I’ve worked in four labs thus far and my current position is, again, temporary. Even in a permanent position, turnover in a lab is so constant that you are still effectively changing labs every few years.

These transitions are so engrained in the scientific culture that staying on in a lab can be viewed as bad for your career. I’ve heard multiple times the advice that, when you do your postdoc, you should change at least two of three things: the institution, the study system, or the question. Presumably, the idea behind this advice is that broadening your experiences also broadens your thinking. Unfortunately, it also takes you out of a lab where you’ve spent a significant amount of time developing your skills and research projects, and sets you wobbling off into a new lab.

Likewise from the PI’s perspective, you put time and money into somebody only to send them away as soon as you start getting a return on your investment. As Mark Cohen wrote earlier this year in a letter to Science, “can you imagine a private-sector environment that demands of its best workers that they find jobs at other companies, rather than nurturing them towards the success of the business overall?” This observation makes me wonder if the frequent turnover in academic science plays a role in driving scientists out of universities and into the private sector.

All of this is not to say that I am unhappy in my new postdoc position. Despite the immediate cost to my productivity, I made the move because I anticipate a net positive in the longer term. However, I do think that it’s worth discussing the trade-off that comes with moving labs, and questioning whether the current emphasis on change really is best for many mentors and mentees, and for science in general.