Brian Chan
Lydia Becker Institute of Immunology and Inflammation
Wellcome Centre for Cell-Matrix Research
Faculty of Biology, Medicine and Health
AV Hill Building, Oxford Road
The University of Manchester
Manchester, M13 9PT
England, UK
ORCID ID: 0000-0002-9451-4621
Website:
Email: brian.chan@manchester.ac.uk
Lydia Becker Institute of Immunology and Inflammation
Wellcome Centre for Cell-Matrix Research
Faculty of Biology, Medicine and Health
AV Hill Building, Oxford Road
The University of Manchester
Manchester, M13 9PT
England, UK
ORCID ID: 0000-0002-9451-4621
Website:
Email: brian.chan@manchester.ac.uk
C.V.
EMPLOYMENT HISTORY
Research technician/lab manager, Faculty of Biology, Medicine and Health, University of Manchester, UK. (May 2016- present).
Scientific Officer, Cancer Research UK Manchester Institute, Paterson Building, University of Manchester, UK. (Sept 2015-May 2016).
Research technician, Institute of Integrative Biology, University of Liverpool, UK (2012- 2015).
Senior research assistant, Center for Infectious Disease Dynamics, The Pennsylvania State University, USA (2008-2011).
Research assistant, Institute of Cell, Animal and Population Biology, University of Edinburgh, UK (1996-2008).
Research technician, Department of Pathology and Infectious Diseases, The Royal Veterinary College, University of London, UK (1993-1996).
DEGREES
BSc (Hons) Parasitology, University of Glasgow (1990-1993).
HND Biological Sciences, Edinburgh Napier University (1987-1990).
EMPLOYMENT HISTORY
Research technician/lab manager, Faculty of Biology, Medicine and Health, University of Manchester, UK. (May 2016- present).
Scientific Officer, Cancer Research UK Manchester Institute, Paterson Building, University of Manchester, UK. (Sept 2015-May 2016).
Research technician, Institute of Integrative Biology, University of Liverpool, UK (2012- 2015).
Senior research assistant, Center for Infectious Disease Dynamics, The Pennsylvania State University, USA (2008-2011).
Research assistant, Institute of Cell, Animal and Population Biology, University of Edinburgh, UK (1996-2008).
Research technician, Department of Pathology and Infectious Diseases, The Royal Veterinary College, University of London, UK (1993-1996).
DEGREES
BSc (Hons) Parasitology, University of Glasgow (1990-1993).
HND Biological Sciences, Edinburgh Napier University (1987-1990).
Research interests
Publications
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during
nematode lung migration (2023). Jesuthas Ajendra, Pedro H. Papotto, James E. Parkinson, Rebecca J. Dodd, André L. Bombeiro, Stella Pearson, Brian H.K. Chan, Julie C. Ribot, Henry J.McSorley, Tara E. Sutherland, Judith E. Allen. Mucosal Immunology. https://doi.org/10.1016/j.mucimm.2023.09.006
T-helper 2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity (2023). Conor M Finlay et al. Immunity. https://doi.org/10.1016/j.immuni.2023.02.016
Maternal γδ T cells shape offspring pulmonary type-2 immunity in a microbiota-dependent manner (2023) . Pedro H. Papotto, Bahtiyar Yilmaz, Gonçalo Pimenta, Sofia Mensurado, Carolina Cunha, Gina Fiala, Daniel Gomes da Costa, Natacha Gonçalves-Sousa, Brian H. K. Chan, Birte Blankenhaus, Tânia Carvalho, Andrew J. Macpherson, Judith E. Allen, Bruno Silva-Santos. Cell reports
DOI:https://doi.org/10.1016/j.celrep.2023.112074
Pollution induces epigenetic effects that are stably transmitted across multiple generations (2022). Harney, E., Paterson, S., Collin, H., Chan, B.H.K., Bennett, D and Plaistow, S.J. Evolution Letters, 6, 118-135. doi:10.1002/evl3.273
IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection (2020). Ajendra, J., Chenery, A., Parkinson, J., Chan, B. H. K., Pearson, S., Colombo, S., Boon, L., Grencis, R., Sutherland, T. & Allen, J., Mucosal Immunology. doi: 10.1038/s41385-020-0318-2
AL Chenery, R Alhallaf, Z Agha , J Ajendra , J Parkinson , MM Cooper , BHK Chan, RM Eichenberger, LA Dent , AAB Robertson, A Kupz , D Brough, A Loukas, TE Sutherland, JE Allen and PR Giacomin. (2019). Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung. Journal of Immunology, . DOI: 10.4049/jimmunol.1900640
Benedetto, A., Bambade, T., Au, C., Tullet, J., Monkhouse, J., Dang. H., Cetbar, K., Cabreiro, F., Chan, B. & Gems, D. (2019). New label‐free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging. Aging Cell. 2019;00:e12998. https://doi. org/10.1111/acel.12998
Huijben, S., Chan, B.H.K., Nelson, W.A., & Read, A.F. (2018). The impact of within-host ecology on the fitness of a drug resistant parasite. Evolution, Medicine and Public Health 2018: 127-137. PDF | Supplementary Data | Raw data
Huijben, S., Chan, B.H.K., & Read, A.F. (2015). Relevance of undetectably rare resistant malaria parasites in treatment failure: experimental evidence from Plasmodium chabaudi. American Journal of Hygiene and Tropical Medicine. 92: 1214-1221. PDF
Blanford, S., Jenkins, N.E., Christian, R., Chan, B.H.K., Luisa, N., Michael, O., Koekemoer, L., Coetzee, M., Read, A.F., & Thomas, M.B. (2012). Storage and persistence of a candidate fungal biopesticide for use against adult malaria vectors. Malaria Journal 11: 354. PDF | Live journal article
Barclay, V.C., Sim, D., Chan, B.H.K., Nell, L.A., Rabaa, M.A., Bell, A.S., Anders, R.F., Read, A.F. (2012). The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi. PLoS Biology 10: e1001368. PDF | Live journal article | Lay synopsis | Media
Bell, A.S, Huijben, S., Paaijmans, K.P., Sim, D., Chan, B.H.K., Nelson, W.A., & Read A.F. (2012). Enhanced transmission of drug-resistance parasites to mosquitoes following drug treatment in rodent malaria. PLoS One 7: e37172. PDF | Live journal article
Paaijmans, K.P., Blanford, S., Chan, B.K. & Thomas, M.B. (2012). Warmer temperatures reduce the vectorial capacity of malaria mosquitoes. Biology Letters. 8: 465-468.
Schneider, P., Chan, B.H.K., Reece, S.E., & Read, A.F. (2008) Does the drug sensitivity of malaria parasites depend on their virulence? Malaria Journal. 7:257. PDF | Commentary
Barclay, V.C., Chan, B.H.K., Anders, R.F., & Read, A.F. (2008) Mixed allele malaria vaccines: host protection and within-host selection. Vaccine. 26: 6099-6107. PDF
Mideo, N., Barclay, V.C., Chan, B.H.K., Savill, N.J., Read, A.F., & Day, T. (2008) Understanding and predicting strain-specific patterns of pathogenesis in the rodent malaria, Plasmodium chabaudi. American Naturalist. 172: 214-238. PDF
Grech, K., Chan, B.H.K., Anders, R.F & Read, A.F. (2008) The impact of immunization on competition with Plasmodium infections. Evolution. 62: 2359-2371. PDF
Long, G.H., Chan. B.H.K., Allen, J.E., Read, A.F., & Graham, A.L. (2008) Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites. BMC Evolutionary Biology 8:128 doi: 10.1186/1471-2148-8-128. PDF | Commentary.
Barclay, V.C., Råberg, L., Chan, B.H.K., Brown, S., Gray, D. & Read, A.F. (2008) CD4+ T cells do not mediate within-host competition between genetically diverse malaria parasite. Proceedings of the Royal Society of London Series B. 275: 1171-1179. PDF
Long, G.H., Chan. B.H.K., Allen, J.E., Read, A.F., & Graham, A.L. (2008) Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection. International Journal for Parasitology. 38: 1073-1081 PDF
Long, G. H., Chan, B. H. K., Allen, J. E., Read, A. F., & Graham, A. L. (2006) Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections. Parasitology. 133: 673-684. PDF.
Wargo, A., Randle, N., Chan, B.H.K., Thompson, J., Read, A.F., & Babiker, H.A. (2006) Plasmodium chabaudi: reverse transcription PCR (RT-PCR) for the detection and quantification of transmission stage malaria parasites. Experimental Parasitology 112: 13-20. PDF
Blanford, S., Chan, B.H.K., Jenkins, N., Sim, D., Turner, R.J., Read, A.F., & Thomas, M.B. (2005) Fungal pathogen reduces potential for malaria transmission. Science 308: 1638-1641. PDF | Supplementary information | Photographs | Correspondence | Commentary | Commentary
de Roode, J.C., Pansini, R., Cheesman, S.J., Helinski, M.E.H., Huijben, S., Wargo, A.R., Bell, A.S., Chan, B.H.K., Walliker, D., & Read, A.F. (2005) Virulence and competitive ability in genetically diverse malaria infections. Proceedings of the National Academy of Sciences USA. 102: 7624-7628 PDF
de Roode, J.C., Read, A.F., Chan, B.H.K., & Mackinnon, M.J 2003. Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. Parasitology. 127: 411-418. PDF
Guinnee, M.A., Gemmill, A.W., Chan, B.H.K., Viney, M.E., & Read, A.F 2003. Host immune status affects maturation time in two nematode species-but not as predicted by a simple life history model. Parasitology. 127: 507-512. PDF
Ferguson, H. M., Mackinnon, M.J,. Chan, B.H.K., & Read, A.F. 2003. Mosquito mortality and the evolution of malaria virulence. Evolution. 57: 2792-2804. PDF
Timms, B., Colegrave, N., Chan, B.H.K., & Read, A.F. 2001. The effect of parasite dose on severity of disease in the rodent malaria Plasmodium chabaudi. Parasitology. 123: 1-11. PDF
Dodd, R.J., Moffatt, D., Vachiteva, M., Parkinson, J.E., Chan, B.H.K., Day, A.J., Allen, J.E. and Sutherland, T.E. (2024), Injury From Nematode Lung Migration Induces an IL-13-Dependent Hyaluronan Matrix. Proteoglycan Research, 2: e70012. https://doi.org/10.1002/pgr2.70012
The genome of Litomosoides sigmodontis illuminates the origins of Y chromosomes in filarial nematodes (2024). Lewis, S., Manuela, K., Chan, B., Wood, J., de la Rosa, P., Allen, J. & Blaxter, M. PLoS Genetics. vol. 20, issue 1. 10.1371/journal.pgen.1011116
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during
nematode lung migration (2023). Jesuthas Ajendra, Pedro H. Papotto, James E. Parkinson, Rebecca J. Dodd, André L. Bombeiro, Stella Pearson, Brian H.K. Chan, Julie C. Ribot, Henry J.McSorley, Tara E. Sutherland, Judith E. Allen. Mucosal Immunology. https://doi.org/10.1016/j.mucimm.2023.09.006
T-helper 2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity (2023). Conor M Finlay et al. Immunity. https://doi.org/10.1016/j.immuni.2023.02.016
Maternal γδ T cells shape offspring pulmonary type-2 immunity in a microbiota-dependent manner (2023) . Pedro H. Papotto, Bahtiyar Yilmaz, Gonçalo Pimenta, Sofia Mensurado, Carolina Cunha, Gina Fiala, Daniel Gomes da Costa, Natacha Gonçalves-Sousa, Brian H. K. Chan, Birte Blankenhaus, Tânia Carvalho, Andrew J. Macpherson, Judith E. Allen, Bruno Silva-Santos. Cell reports
DOI:https://doi.org/10.1016/j.celrep.2023.112074
Pollution induces epigenetic effects that are stably transmitted across multiple generations (2022). Harney, E., Paterson, S., Collin, H., Chan, B.H.K., Bennett, D and Plaistow, S.J. Evolution Letters, 6, 118-135. doi:10.1002/evl3.273
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection (2021). Chenery, A., Rosini, S., Parkinson, J.E., Ajendra, J., Herrera, J.A., Lawless, C., Chan, B.H.K., Loke, P., MacDonald, A.S., Kadler, K.E., Sutherland, T.E., & Allen, J.E. Life Science Alliance. DOI: 10.26508/lsa.202001000
IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection (2020). Ajendra, J., Chenery, A., Parkinson, J., Chan, B. H. K., Pearson, S., Colombo, S., Boon, L., Grencis, R., Sutherland, T. & Allen, J., Mucosal Immunology. doi: 10.1038/s41385-020-0318-2
AL Chenery, R Alhallaf, Z Agha , J Ajendra , J Parkinson , MM Cooper , BHK Chan, RM Eichenberger, LA Dent , AAB Robertson, A Kupz , D Brough, A Loukas, TE Sutherland, JE Allen and PR Giacomin. (2019). Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung. Journal of Immunology, . DOI: 10.4049/jimmunol.1900640
Benedetto, A., Bambade, T., Au, C., Tullet, J., Monkhouse, J., Dang. H., Cetbar, K., Cabreiro, F., Chan, B. & Gems, D. (2019). New label‐free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging. Aging Cell. 2019;00:e12998. https://doi. org/10.1111/acel.12998
Huijben, S., Chan, B.H.K., Nelson, W.A., & Read, A.F. (2018). The impact of within-host ecology on the fitness of a drug resistant parasite. Evolution, Medicine and Public Health 2018: 127-137. PDF | Supplementary Data | Raw data
Huijben, S., Chan, B.H.K., & Read, A.F. (2015). Relevance of undetectably rare resistant malaria parasites in treatment failure: experimental evidence from Plasmodium chabaudi. American Journal of Hygiene and Tropical Medicine. 92: 1214-1221. PDF
Blanford, S., Jenkins, N.E., Christian, R., Chan, B.H.K., Luisa, N., Michael, O., Koekemoer, L., Coetzee, M., Read, A.F., & Thomas, M.B. (2012). Storage and persistence of a candidate fungal biopesticide for use against adult malaria vectors. Malaria Journal 11: 354. PDF | Live journal article
Barclay, V.C., Sim, D., Chan, B.H.K., Nell, L.A., Rabaa, M.A., Bell, A.S., Anders, R.F., Read, A.F. (2012). The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi. PLoS Biology 10: e1001368. PDF | Live journal article | Lay synopsis | Media
Bell, A.S, Huijben, S., Paaijmans, K.P., Sim, D., Chan, B.H.K., Nelson, W.A., & Read A.F. (2012). Enhanced transmission of drug-resistance parasites to mosquitoes following drug treatment in rodent malaria. PLoS One 7: e37172. PDF | Live journal article
Paaijmans, K.P., Blanford, S., Chan, B.K. & Thomas, M.B. (2012). Warmer temperatures reduce the vectorial capacity of malaria mosquitoes. Biology Letters. 8: 465-468.
Schneider, P., Chan, B.H.K., Reece, S.E., & Read, A.F. (2008) Does the drug sensitivity of malaria parasites depend on their virulence? Malaria Journal. 7:257. PDF | Commentary
Barclay, V.C., Chan, B.H.K., Anders, R.F., & Read, A.F. (2008) Mixed allele malaria vaccines: host protection and within-host selection. Vaccine. 26: 6099-6107. PDF
Mideo, N., Barclay, V.C., Chan, B.H.K., Savill, N.J., Read, A.F., & Day, T. (2008) Understanding and predicting strain-specific patterns of pathogenesis in the rodent malaria, Plasmodium chabaudi. American Naturalist. 172: 214-238. PDF
Grech, K., Chan, B.H.K., Anders, R.F & Read, A.F. (2008) The impact of immunization on competition with Plasmodium infections. Evolution. 62: 2359-2371. PDF
Long, G.H., Chan. B.H.K., Allen, J.E., Read, A.F., & Graham, A.L. (2008) Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites. BMC Evolutionary Biology 8:128 doi: 10.1186/1471-2148-8-128. PDF | Commentary.
Barclay, V.C., Råberg, L., Chan, B.H.K., Brown, S., Gray, D. & Read, A.F. (2008) CD4+ T cells do not mediate within-host competition between genetically diverse malaria parasite. Proceedings of the Royal Society of London Series B. 275: 1171-1179. PDF
Long, G.H., Chan. B.H.K., Allen, J.E., Read, A.F., & Graham, A.L. (2008) Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection. International Journal for Parasitology. 38: 1073-1081 PDF
Long, G. H., Chan, B. H. K., Allen, J. E., Read, A. F., & Graham, A. L. (2006) Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections. Parasitology. 133: 673-684. PDF.
Wargo, A., Randle, N., Chan, B.H.K., Thompson, J., Read, A.F., & Babiker, H.A. (2006) Plasmodium chabaudi: reverse transcription PCR (RT-PCR) for the detection and quantification of transmission stage malaria parasites. Experimental Parasitology 112: 13-20. PDF
Blanford, S., Chan, B.H.K., Jenkins, N., Sim, D., Turner, R.J., Read, A.F., & Thomas, M.B. (2005) Fungal pathogen reduces potential for malaria transmission. Science 308: 1638-1641. PDF | Supplementary information | Photographs | Correspondence | Commentary | Commentary
de Roode, J.C., Pansini, R., Cheesman, S.J., Helinski, M.E.H., Huijben, S., Wargo, A.R., Bell, A.S., Chan, B.H.K., Walliker, D., & Read, A.F. (2005) Virulence and competitive ability in genetically diverse malaria infections. Proceedings of the National Academy of Sciences USA. 102: 7624-7628 PDF
de Roode, J.C., Read, A.F., Chan, B.H.K., & Mackinnon, M.J 2003. Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. Parasitology. 127: 411-418. PDF
Guinnee, M.A., Gemmill, A.W., Chan, B.H.K., Viney, M.E., & Read, A.F 2003. Host immune status affects maturation time in two nematode species-but not as predicted by a simple life history model. Parasitology. 127: 507-512. PDF
Ferguson, H. M., Mackinnon, M.J,. Chan, B.H.K., & Read, A.F. 2003. Mosquito mortality and the evolution of malaria virulence. Evolution. 57: 2792-2804. PDF
Timms, B., Colegrave, N., Chan, B.H.K., & Read, A.F. 2001. The effect of parasite dose on severity of disease in the rodent malaria Plasmodium chabaudi. Parasitology. 123: 1-11. PDF
Miscellaneous
- Martial arts: Karate, jujitsu and Brazilian jiu jitsu.
- Volleyball
- Racket sports- badminton, tennis and squash.
- Photography see a selection of my photos here: Flickr
- Cycling
- Cooking